Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>
Physiological targets and you can pharmacology of curcumin
Guide ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca M. Romero, Ian S Haworth Curcumin ‘s the significant component of the latest red-colored dye away from turmeric, an enthusiastic Indian liven which is taken from new rhizome of one’s tropical plant Curcuma longa, and this belongs to the Zingiberaceae friends. Inside section, we discuss the pharmacological circumstances off curcumin and you will speak about the molecular bases for those issues. We up coming review brand new demonstrated and you will potential medical spends out-of curcumin. Curcumin is well known usually just like the a curative agent, but its mechanism out-of action was detail by detail. The latest pharmacological ramifications of curcumin seem to be the consequence of good synergism from networking sites out of weak biochemical interactions having numerous physiological goals for the interconnected signaling pathways. Such goals tend to be minerals particularly cyclooxygenase, lipoxygenase and proteins kinases, and you can transcription items for example NF-?B, STAT and Nrf2. Modulation ones particles affects downstream affectors that make the brand new antiinflammatory, anti-oxidant, chemopreventive, anticancer, and you can antimicrobial activities off curcumin. These types of effects was indeed checked when you look at the systematic samples out of curcumin for discomfort and inflammatory illness, cancer, Alzheimer problem, aerobic diseases, and you may diabetes. The new trials have tried adjustable dosage out-of curcuminwith other wavelengths and you will stage, on standard conclusion you to large dosages regarding curcumin during the amount of grams must obtain therapeutic effects. Find out more
Curcumin: Synthesis, Emerging Character from inside the Soreness Administration and you will Health Ramifications
Publication Part Examples of plant-derived pharmaceuticals having become the notice away from carried on and you will great search and you may creativity notice have, up to now, come a little scarce. Shortly after a long period, the final 20 years had been characterized by a beneficial 100-fold escalation in how many scientific posts typed per year you to are out of significance into the means to access curcumin inside biomedicine. Read more
Design, synthesis and you will physical circumstances from curcumin prodrugs
Book ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca M. Romero, Ian S Haworth Curcumin has some prospective pharmacological effects and may also have therapeutic apps in a lot of condition states, once the talked about in more detail in the previous chapter. Although not, the possibility systematic effectiveness out of curcumin is bound by the the physicochemical features out-of worst water solubility and you can instability, and that cause reduced bioavailability. Prodrugs out of curcumin give an effective way to improvement of your own biopharmaceutical and pharmacokinetic features, and could succeed exploitation of one’s pharmacological results of curcumin. Within this part, i basic opinion the new physicochemical and you siteyi buradan ziyaret edin can pharmacokinetics out-of curcumin. We up coming determine the style of curcumin prodrugs which have enhanced h2o solubility and you can enhanced toxins balances which can be translated back to free curcumin through to bioactivation within the vivo. I high light latest success in this field, that have a focus on the design, synthesis and investigations away from prodrugs considering promoieties and additionally proteins, fatty acids, nucleic acids, dicarboxylic acids, and you may polymeric material such as for instance hyaluronic acidic and polyethylene glycol. So it section contains the reason behind optimization of one’s physicochemical and biopharmaceutical properties and also the physiological items off curcumin prodrugs, toward goal using of them curcumin derivatives from inside the scientific applications. Find out more